Gene information
Official symbol SCN5A
Official full name sodium voltage-gated channel alpha subunit 5
Gene type protein-coding gene
Chromosome3p22.2
Alias symbolNav1.5; LQT3; HB1; HBBD; PFHB1; IVF; HB2; HH1; SSS1; CDCD2; CMPD2; ICCD
Previous symbolCMD1E
Gene familySodium voltage-gated channel alpha subunits
Resources
Entrez Gene 6331
HGNC HGNC:10593
Ensembl ENSG00000183873
Vega OTTHUMG00000156166
UCSC uc062ihi.1
GO terms: 93 records
GO Description Category LogP Number of genes Detail
GO:0001508 action potential GO Biological Processes -2.21965331 5 More
GO:0002027 regulation of heart rate GO Biological Processes -9.97103962 23 More
GO:0002028 regulation of sodium ion transport GO Biological Processes -2.33647794 5 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003015 heart process GO Biological Processes -12.3962712 26 More
GO:0003161 cardiac conduction system development GO Biological Processes -7.69659659 12 More
GO:0003205 cardiac chamber development GO Biological Processes -16.2154327 37 More
GO:0003231 cardiac ventricle development GO Biological Processes -15.0525208 31 More
GO:0003254 regulation of membrane depolarization GO Biological Processes -7.35217119 13 More
GO:0005261 cation channel activity GO Molecular Functions -1.68739377 23 More
GO:0005901 caveola GO Cellular Components -18.8033423 19 More
GO:0005911 cell-cell junction GO Cellular Components -3.41801827 38 More
GO:0006814 sodium ion transport GO Biological Processes -1.68216350 6 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006942 regulation of striated muscle contraction GO Biological Processes -11.0877013 23 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0010035 response to inorganic substance GO Biological Processes -29.1720710 89 More
GO:0010038 response to metal ion GO Biological Processes -20.5090881 61 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0014704 intercalated disc GO Cellular Components -1.78827574 6 More
GO:0014706 striated muscle tissue development GO Biological Processes -21.0654252 44 More
GO:0017134 fibroblast growth factor binding GO Molecular Functions -2.61017926 3 More
GO:0019226 transmission of nerve impulse GO Biological Processes -1.53982958 3 More
GO:0019228 neuronal action potential GO Biological Processes -2.27643592 3 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0021537 telencephalon development GO Biological Processes -6.21909725 29 More
GO:0021549 cerebellum development GO Biological Processes -2.08731679 10 More
GO:0022037 metencephalon development GO Biological Processes -1.83324821 10 More
GO:0030001 metal ion transport GO Biological Processes -7.54203733 26 More
GO:0030029 actin filament-based process GO Biological Processes -9.62516039 61 More
GO:0030048 actin filament-based movement GO Biological Processes -8.41720734 20 More
GO:0030900 forebrain development GO Biological Processes -11.1545964 48 More
GO:0031625 ubiquitin protein ligase binding GO Molecular Functions -1.82192201 21 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0034702 ion channel complex GO Cellular Components -2.54472403 10 More
GO:0034703 cation channel complex GO Cellular Components -2.87762227 9 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0035637 multicellular organismal signaling GO Biological Processes -4.89020616 9 More
GO:0035725 sodium ion transmembrane transport GO Biological Processes -1.81540720 5 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0042475 odontogenesis of dentin-containing tooth GO Biological Processes -4.56077482 13 More
GO:0042476 odontogenesis GO Biological Processes -9.69427751 24 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043502 regulation of muscle adaptation GO Biological Processes -16.8828965 29 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044325 transmembrane transporter binding GO Molecular Functions -3.08506458 7 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0046873 metal ion transmembrane transporter activity GO Molecular Functions -1.47457965 10 More
GO:0048471 perinuclear region of cytoplasm GO Cellular Components -8.50169248 66 More
GO:0048738 cardiac muscle tissue development GO Biological Processes -21.5979622 44 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050998 nitric-oxide synthase binding GO Molecular Functions -3.36388958 3 More
GO:0051592 response to calcium ion GO Biological Processes -7.43492702 23 More
GO:0051899 membrane depolarization GO Biological Processes -3.15848951 8 More
GO:0055117 regulation of cardiac muscle contraction GO Biological Processes -9.51337974 19 More
GO:0060047 heart contraction GO Biological Processes -8.83781505 20 More
GO:0060048 cardiac muscle contraction GO Biological Processes -7.88412825 17 More
GO:0060306 regulation of membrane repolarization GO Biological Processes -5.46127869 10 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization GO Biological Processes -5.41391056 4 More
GO:0060537 muscle tissue development GO Biological Processes -18.3336784 54 More
GO:0061337 cardiac conduction GO Biological Processes -5.79383245 8 More
GO:0070252 actin-mediated cell contraction GO Biological Processes -7.79385832 16 More
GO:0071241 cellular response to inorganic substance GO Biological Processes -4.23170629 23 More
GO:0071248 cellular response to metal ion GO Biological Processes -4.26641514 21 More
GO:0086001 cardiac muscle cell action potential GO Biological Processes -2.56813882 4 More
GO:0086003 cardiac muscle cell contraction GO Biological Processes -2.74134667 4 More
GO:0086010 membrane depolarization during action potential GO Biological Processes -2.27643592 3 More
GO:0086019 cell-cell signaling involved in cardiac conduction GO Biological Processes -3.56106200 4 More
GO:0086065 cell communication involved in cardiac conduction GO Biological Processes -3.81986526 5 More
GO:0086067 AV node cell to bundle of His cell communication GO Biological Processes -3.72958795 3 More
GO:0086069 bundle of His cell to Purkinje myocyte communication GO Biological Processes -4.75202065 4 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0098655 cation transmembrane transport GO Biological Processes -3.98966777 20 More
GO:0098660 inorganic ion transmembrane transport GO Biological Processes -4.47276690 21 More
GO:0098662 inorganic cation transmembrane transport GO Biological Processes -4.65654157 20 More
GO:0098797 plasma membrane protein complex GO Cellular Components -14.6387951 39 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0098900 regulation of action potential GO Biological Processes -5.92071483 13 More
GO:0099623 regulation of cardiac muscle cell membrane repolarization GO Biological Processes -3.70345918 7 More
GO:1902495 transmembrane transporter complex GO Cellular Components -2.24412383 11 More
GO:1903115 regulation of actin filament-based movement GO Biological Processes -5.35296451 10 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04261 Adrenergic signaling in cardiomyocytes KEGG Pathway -3.35554526 8 More
Drug-Gene interaction
view
Related drugs: 85 records
Drug name Interaction type Source PMID View
amiodarone PharmGKB view
aprindine inhibitor TdgClinicalTrial 16536441660104 view
articaine hydrochloride blocker ChemblInteractions view
azd1305 blocker ChemblInteractions view
azd7009 blocker ChemblInteractions view
benoxinate hydrochloride blocker ChemblInteractions view
benzonatate antagonist TdgClinicalTrialTENDTTD 2325897028334901 view
bepridil TdgClinicalTrialTEND view
carbamazepine inhibitorblocker TdgClinicalTrialChemblInteractionsTEND 2064390412391287171392841701642320526191 view
chloroprocaine hydrochloride blocker ChemblInteractions view
clomipramine DTC 26372073 view
cocaine inhibitor TdgClinicalTrialTENDPharmGKB 17038146987613715880981 view
dibucaine inhibitor TdgClinicalTrialTENDTTD 1235456797426848798723117523521713928417016423 view
dibucaine hydrochloride blocker ChemblInteractions view
disopyramide inhibitor TdgClinicalTrialTENDPharmGKBTTD 15897781117523521502807311196553 view
disopyramide phosphate blocker ChemblInteractions view
dronedarone hydrochloride blocker ChemblInteractions view
dyclonine TTD view
dyclonine hydrochloride blocker ChemblInteractions view
encainide inhibitor TdgClinicalTrialTEND 98352601675128716531231175235217016423 view
erlosamide blocker ChemblInteractions view
eslicarbazepine blocker TdgClinicalTrialChemblInteractions view
eslicarbazepine acetate blocker ChemblInteractions view
ethotoin blockerinhibitor TdgClinicalTrialChemblInteractionsTENDTTD 15066664117523521713928417016423 view
etidocaine hydrochloride blocker ChemblInteractions view
evenamide blocker ChemblInteractions view
flecainide inhibitor TdgClinicalTrialTENDPharmGKB 113077831075805310617684109619551260108411752352115355801527204511196553 view
flecainide acetate blocker ChemblInteractions view
fosphenytoin inhibitor TdgClinicalTrialTENDTTD 15066664150014031175235220298965 view
fosphenytoin sodium blocker ChemblInteractions view
hexylcaine inhibitor TdgClinicalTrialTENDTTD 117523521713928417016423 view
hexylcaine hydrochloride blocker ChemblInteractions view
indecainide inhibitor TdgClinicalTrialTENDTTD 268839124766266206315117523521713928417016423 view
indecainide hydrochloride blocker ChemblInteractions view
irampanel blocker ChemblInteractions view
lamotrigine blocker ChemblInteractions view
licarbazepine TdgClinicalTrial view
lidocaine blockerinhibitor TdgClinicalTrialChemblInteractionsTENDPharmGKB 166866851744591917016511168407982058554419088384 view
lidocaine hydrochloride blocker ChemblInteractions view
lithium PharmGKB view
lomerizine TTD view
mephenytoin blockerinhibitor TdgClinicalTrialChemblInteractionsTENDTTD 150666641500140311752352 view
mepivacaine hydrochloride blocker ChemblInteractions view
merethoxylline procaine blocker ChemblInteractions view
mexiletine inhibitor TdgClinicalTrialTENDPharmGKBTTD 12650887161684891260487911752352121237671267607011196553 view
mexiletine hydrochloride blocker ChemblInteractions view
moricizine inhibitor TdgClinicalTrialTENDTTD 12402511117523521713928417016423 view
moricizine hydrochloride blocker ChemblInteractions view
nerispirdine blocker ChemblInteractions view
nktr-171 blocker ChemblInteractions view
orphenadrine citrate blocker ChemblInteractions view
orphenadrine hydrochloride blocker ChemblInteractions view
oxcarbazepine inhibitorblocker TdgClinicalTrialChemblInteractionsTEND 171392842050272417016423 view
phenacemide blocker ChemblInteractions view
phenazopyridine hydrochloride blocker ChemblInteractions view
phenytoin blockerinhibitor TdgClinicalTrialChemblInteractionsTEND 2267815915066615001403 view
phenytoin sodium blocker ChemblInteractions view
pilsicainide PharmGKB 31484910 view
prilocaine inhibitorblocker TdgClinicalTrialChemblInteractionsTENDTTD 117523521713928417016423 view
prilocaine hydrochloride blocker ChemblInteractions view
primidone blocker ChemblInteractions view
procainamide inhibitor TdgClinicalTrialTENDPharmGKB 111557781122579011839626117523521044330410662748 view
procainamide hydrochloride blocker ChemblInteractions view
procaine hydrochloride blocker ChemblInteractions view
propafenone inhibitor TdgClinicalTrialTENDPharmGKB 164631411713928417016423 view
propafenone hydrochloride blocker ChemblInteractions view
proparacaine hydrochloride blocker ChemblInteractions view
propoxycaine hydrochloride blocker ChemblInteractions view
quinidine inhibitor TdgClinicalTrialTENDPharmGKB 170235041755618616972995206855731175235216138883947697415877619 view
quinidine gluconate blocker ChemblInteractions view
quinidine polygalacturonate blocker ChemblInteractions view
quinidine sulfate blocker ChemblInteractions view
ralfinamide blocker ChemblInteractions view
ranolazine blockerinhibitor TdgClinicalTrialChemblInteractionsTEND 1722047119077543 view
riluzole blockerinhibitor TdgClinicalTrialChemblInteractions 205906011713928492623341701642312440368 view
ropivacaine hydrochloride blocker ChemblInteractions view
rufinamide blocker ChemblInteractions view
safinamide TdgClinicalTrial view
tetracaine blocker ChemblInteractions view
tetracaine hydrochloride blocker ChemblInteractions view
tetrodotoxin TdgClinicalTrialTTD view
tocainide inhibitor TdgClinicalTrialTEND 1095355111752352 view
tocainide hydrochloride blocker ChemblInteractions view
topiramate blocker ChemblInteractions view
zonisamide blockerinhibitor TdgClinicalTrialChemblInteractions 19557119200014331994816815511691200251281470446318433351 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
NM_198056.3:c.-52-562G>C genomics ventricular tachycardia[prognosis (bad)] acute ST elevation myocardial infarction Jabbari R et al. PLoS One. 2017
NC_000003.12:g.38592432G>C genomics ventricular arrhythmia[prognosis (bad)] myocardial infarction Foddha H et al. Adv Clin Exp Med. 2020
All rights reserved: Soochow University Center for Systems Biology